64-year-old male with constitutional symptoms and pancytopenia
- 2024, Volume 43 - Number 1
- Published: June 28, 2024
64-year-old male with constitutional symptoms and pancytopenia
Fernando Martín-Moro 1, Juan Marquet 2, Mónica García-Cosío-Piqueras 3, Eulalia Rodríguez-Martín 4, Rubén Ballester 4, María Talavera-YaguÌez 5, José A. García-Vela 6, Pilar Herrera-Puente 1, Gemma Moreno-Jiménez 1, Francisco J. López-Jiménez 1, Jesús Villarrubia-Espinosa 1, Miguel Piris-Villaespesa 1
1 Servicio de Hematología y Hemoterapia, Hospital Universitario Ramón y Cajal, Madrid, España; 2 Servicio de Hematología, Hospital Universitario Ramón y Cajal, Madrid, España; 3 Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, España; 4 Servicio de Inmunología, Hospital Universitario Ramón y Cajal, Madrid, España; 5 Servicio de Genética, Hospital Universitario Ramón y Cajal, Madrid, España; 6 Servicio de Hematología y Hemoterapia, Hospital Universitario de Getafe. Madrid, España
Fernando Martín-Moro, Juan Marquet, Mónica García-Cosío-Piqueras, Eulalia Rodríguez-Martín, Rubén Ballester, María Talavera-YaguÌez, José A. García-Vela, Pilar Herrera-Puente, Gemma Moreno-Jiménez, Francisco J. López-Jiménez, Jesús Villarrubia-Espinosa, Miguel Piris-Villaespesa
La información completa de afiliaciones y autor de correspondencia está disponible en la versión original en PDF.
*Correspondence: Fernando Martín-Moro. Email: fmartinmoro@usal.es
Summary
Plasmacytoid dendritic cells (pDCs) are part of the immune system and account a minor population in the bone marrow. Recently, clonal proliferations of pDCs have been described in association with some cases of hematological neoplasms, predominantly of myeloid lineage. Here is presented the case report of a patient with a new-onset myelodysplastic syndrome (MDS) and pDC expansion, showing the relevance of the integrated diagnosis to differentiate between MDS-associated clonal pDC proliferation and blastic plasmacytoid dendritic cell neoplasm concurrent with MDS, due to its prognostic and therapeutic implications.
Keywords: Cytomorphology. Flow cytometry. Histology. Genetics. Molecular biology.
